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Preparation of Suppositories

Compounding Corner – April 2017

You receive the following prescription in your pharmacy:

Patient: Jimmy R.

Age: 5

Sex: M

Prescription: 12 Glycerin suppositories using the following formula:

Glycerin Suppositories      (105 g)

Glycerin                                   91 g

Sodium stearate                  9 g

Purified water                      5 g

Directions: Insert ONE suppository into the rectum when required.


  1. What is the use of this product?
  2. Explain the role of the components in this preparation.
  3. In compounding this prescription, you calculate for two extra suppositories to account for unavoidable loss in compounding. Calculations are therefore based on the amounts required to prepare 14 suppositories. What is the mass of glycerin-sodium stearate base that would be needed to prepare 14 child-size (2 g suppositories)?
  4. What size of suppository mold would you have used for an infant? For an adult?
  5. How many grams of sodium stearate are required to fill the prescription?
  6. What is the use of sodium stearate in this preparation?
  7. What is the volume of purified water required?
  8. What precautions should be taken when choosing the container of the suppositories?
  9. What are the labelling considerations for this preparation?


Indications for question 3: The glycerin-sodium stearate base has a density of 1.25. To correctly calculate the quantities required, the amount that would be required to fill the nominal weight will need to be multiplied by a factor of 1.25.

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  1. This product is used to treat constipation.
  2. Glycerin, a hygroscopic material, contributes to the laxative effect of the suppository by drawing water from the intestine and also from its irritant action on the mucous lining. The sodium stearate, a soap, is the solidifying agent in the suppository and may also contribute to the laxative action.
  3. A 1 g mold is usually used for an infant’s suppository, and a 4 g mold for an adult’s suppository.
  4. 14*2*1.25 = 35 g, total weight of mixture
  5. 91 (g)/105 (g) = x (g)/35 (g) ==> x= 30.3 g of glycerin
  6. 9 (g)/105 (g) = x (g)/35 (g) ==> x= 3 g of sodium stearate
  7. 5 (g)/105 (g) = x (g)/35 (g) ==> x= 1.7 g of purified water, which corresponds to 1.7 mL.
  8. The glycerin suppositories have the disadvantage of being very hygroscopic, therefore they must be protected from atmosphere and wrapped in waxed paper or tin foil. The suppositories could also be made in a disposable mold.
  9. The product name and list of the ingredients and their quantities.

The size of the suppositories (2 g) could be added as suppositories can be available in different sizes.

Product-specific cautions: ‘For rectal use only’ will need to be added to the label as the products are suppositories for rectal use; ‘Keep out of the reach of children’

Directions to patient:’ Insert ONE suppository into the rectum when required.’

Expiration date: 3 months.




Asociaón de Estudiantes de Farmacia  de la República Argentina

National EXco members:

President: Roberto Chaile.

Secretary General: Florencia Flores.

Treasurer: Franco Rizo.

Membership Secretary: Anahi Zanetti.

Communication Secretary: Bruno Da Passano.

Public Health Secretary: Federico Verona.

Academic and Pharmacy Education Secretary: Estefania Peralta Lopez.

Auditing Committee: Chair: Telma Acosta.

Substitute: Melissa del Rosario Tolava .

IPSF Contact Person: Cecilia Zuccarelli.

Student Exchange Officer: Damian Romero.

AEFRA (Argentine Republic Pharmacy Students’ Association) is a non-governmental organization for pharmacy students, founded in 2012 in San Luis. We are currently based all over the country, and we are dedicated to lead basic processes for the academic and professional development to all our members, through educational, social and cultural activities, seeking to benefit the national pharmaceutical community and the population in general.

We think AEFRA’s is one of a kind association. If you are wondering why, the answer is very simple: we, the Argentinian, are spontaneous, outgoing, supportive, and we have this unique feature – we always do whatever we really want (even if we don’t have the minimal idea of what we are doing!). This particular and rare feature, which sometimes is confused with stubbornness, always pushed us forward to face all the dreams and challenges along the way in our short life as an association. A convincing proof of this, is that we as a 4-year old association, organized 4 National Congresses, the 9th Pan American Regional Symposium, 3 AEFRA’s Solidary Programmes, the Students and Young Pharmacists’ Package for FIP World Congress 2016, and soon in 2018, we will be proud of hosting the 64th IPSF World Congress. In addition, we got the IPSF Full membership in 2015, and won several grants as the Best New Association in the world in 2015, Best Regional Association two years in a row (2015- 2016), and lastly Best Regional Contact Person and Best regional SEO in 2016. All of these achievements have been possible thanks to our strong will and sacrifice to move forward above all obstacles and always with the strongest passion and love for pharmacy that you will ever find in anyone. Therefore, if you meet an AEFRA member sometime, you will get to know a rare mixed of steel spirit, unbreakable will, giant heart and passionate pharmacy lover, with our most delighting feature – wherever we are, we are always going to bring joy and happiness to all our friends and partners. Wishful that one day you could visit us and know our wonderful country, we invite you to come to Mendoza in 2018 to taste the most delicious wine and beautiful landscapes. There you will learn about pharmacy innovation and enroll to the global improvement of pharmacy that IPSF and AEFRA both support since their creation.


Portuguese Association Of Pharmacy Students

Website​ | Facebook

The National ExCo members

  • President: Diana Carvalho.
  • Vice President for External Relations: Manuel Talhinhas.
  • Vice President for Internal Relations: Sofia Fonte.
  • Treasurer: Bárbara Ramalho.
  • Secretary General: Rodrigo Ramos. 
  • Department of Health Promotion and Education: Carolina Rodrigues. 
  • Department of Internships and Professional Development: Adriana Machado.
  • Department of Education and Formation: Diana Lopes.
  • Design and Image Department: Luís Silva.
  • Commercial Department: João Paulino.
  • Cultural Department: Patrícia Capucho.
  • EPSA Liaison Secretary/ National IMP Coordinator: Leonor Pereira.
  • IPSF Contact Person/Student Exchange Officer: Raquel Oliveira.

Our motto is:

“A APEF de hoje, na génese e vanguarda do Farmacêutico do futuro.”  – Today´s APEF, at the genesis and vanguard of the future pharmacist.

The Portuguese Association of Pharmacy Students was founded on December 9, 1998. It emerged as a response to the inherent need to represent students of the Integrated Masters in Pharmaceutical Sciences. Together, they have built a cohesive and united front, which is designed to defend students’ interests and complement the curriculum of Pharmaceutical Sciences Teaching Institutions from all over the country.

Bearing in mind that the pharmacist brings together unique values, APEF intends to complement what has already been taught in teaching institutions with new and bold perspectives of training and education, health education, knowledge of career opportunities, international presence, commercial and marketing vision, media and image strategy and cultural linkage.




March Crazy Clinical Corner – Pain Management

Patient case: 

Jacques, a 34 year old man comes into your pharmacy looking for something for pain. He explains that he was in an accident a few months ago. He is recovering well and his injuries have healed but he still has quite sharp pains in his leg. He did have some strong pain relief, oxycodone, prescribed for him previously but he ran out of it a while ago. He has been taking paracetamol and ibuprofen regularly but finds that isn’t helping, and low dose codeine helps a little but he doesn’t want to take too much codeine. You recommend that he goes to the doctor’s to get it properly assessed. Some time later he returns with a prescription for gabapentin 600 mg three times a day.



  1. Jacques has no history of epilepsy or seizures. Why has an antiepileptic been prescribed?
  2. What kind of pain is Jacques experiencing?
  3. What are the symptoms of this kind of pain?
  4. Is the choice of medicine and the dose prescribed appropriate? If not, what would be better?
  5. Discussion question  (please add your response to the comments below)5. what non pharmacological options to help Jacques with his pain?


جاك، رجل يبلغ من العمر 34 عاما جاء إلى الصيدلية بحثاً عن حل للألم. أخبرك أنه تعرض إلى حادث قبل بضعة أشهر وهو الآن يتعافى بشكل جيد إضافةً إلى التئام إصاباته ولكنه لا يزال يعاني آلاما حادة جدا في قدمه.  سابقا كانت بحوزته وصفة أوكسيكودون لتخفيف الآلام ، ولكنه نفد منذ فترة. أخذ الباراسيتامول والإيبوبروفين بانتظام ولكن ذلك لم يساعده.  رغم أن جرعة الكودين المنخفضة ساعدته قليلا إلا أنه لا يريد إستهلاك الكثير منها. نصحته بزيارة الطبيب للحصول على تقييم ملائم.بعد فترة عاد جاك و معه وصفة طبية   فيها  600 ملغ غابابنتين ثلاث مرات في اليوم

 لا يعاني جاك من مرض الصرع و لم تصادفه أي نوبة مرضية من قبل. لماذا تم وصف مضاد للصرع؟

 ما هو سبب الألم الذي يعاني منه جاك ؟

ما هي أعراض هذا النوع من الألم؟

 هل اختيار الدواء والجرعة الموصوفة مناسب؟ إن لم يكن كذلك، ما هو الأفضل؟

سؤال للمناقشة (يرجى إضافة ردك على التعليقات أدناه)

 ما الخيارات الموجودة لتخفيف ألم جاك دون اللجوء إلى الأدوية؟



Jacques, un homme de 34 ans se rend à votre pharmacie à la recherche de quelque chose contre la douleur. Il vous explique qu’il était victime d’un accident il ya quelques mois. Il s’en est bien remis et ses blessures ont guéri, mais il a encore des douleurs très vives qui persistent au niveau de sa jambe. Dans le passé, Il a eu une prescription pour l’oxycodone ce qui permis de soulager sa douleur mais il a épuisé ce médicament. Il prends du paracétamol et de l’ibuprofène régulièrement, mais trouve que cela ne l’aide pas beaucoup, et la faible dose de codéine le soulage peu, mais il ne veut pas en prendre trop. Vous recommandez qu’il consulte le médecin pour une évaluation appropriée. Quelque temps plus tard, il revient avec une ordonnance de 600 mg de gabapentine à prendre trois fois par jour.


  1. Jacques n’a pas d’antécédents d’épilepsie ou de convulsions. Pourquoi un antiépileptique a-t-il été prescrit?
  2. Quel genre de douleur ressens Jacques?
  3. Quels sont les symptômes de ce type de douleur?
  4. Le choix du médicament et de la dose prescrite est-il approprié? Sinon, qu’est ce qui serait mieux?


Question de discussion (veuillez ajouter votre réponse aux commentaires ci-dessous)

  1. quelles options non pharmacologiques peuvent aider Jacques et sa douleur?
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